ICM UWhttps://depot.ceon.pl/handle/123456789/55332024-03-29T00:42:24Z2024-03-29T00:42:24ZConvexity and Monotonicity in Language Coordination: Simulating the Emergence of Semantic Universals in Populations of Cognitive AgentsGierasimczuk, NinaKalociński, DariuszRakowski, FranciszekUszyński, Jakubhttps://depot.ceon.pl/handle/123456789/240242024-03-15T15:05:15Z2023-01-01T00:00:00ZConvexity and Monotonicity in Language Coordination: Simulating the Emergence of Semantic Universals in Populations of Cognitive Agents
Gierasimczuk, Nina; Kalociński, Dariusz; Rakowski, Franciszek; Uszyński, Jakub
Natural languages vary in their quantity expressions, but the variation seems to be constrained by general properties, so-called universals. Their explanations have been sought among constraints of human cognition, communication, complexity, and pragmatics. In this article, we apply a state-of-the-art language coordination model to the semantic domain of quantities to examine whether two quantity universals—monotonicity and convexity—arise as a result of coordination. Assuming precise number perception by the agents, we evolve communicatively usable quantity terminologies in two separate conditions: a numeric-based condition in which agents communicate about a number of objects and a quotient-based condition in which agents communicate about the proportions. We find out that both universals take off in all conditions but only convexity almost entirely dominates the emergent languages. Additionally, we examine whether the perceptual constraints of the agents can contribute to the further development of universals. We compare the degrees of convexity and monotonicity of languages evolving in populations of agents with precise and approximate number sense. The results suggest that approximate number sense significantly reinforces monotonicity and leads to further enhancement of convexity. Last but not least, we show that the properties of the evolved quantifiers match certain invariance properties from generalized quantifier theory.
2023-01-01T00:00:00ZSIR-Model for HouseholdsDonges, PhilippGotz, ThomasKruger, TyllNiedzielewski, KarolPriesemann, ViolaSchafer, Moritzhttps://depot.ceon.pl/handle/123456789/227642023-10-11T15:10:30Z2023-01-11T00:00:00ZSIR-Model for Households
Donges, Philipp; Gotz, Thomas; Kruger, Tyll; Niedzielewski, Karol; Priesemann, Viola; Schafer, Moritz
Households play an important role in disease dynamics. Many infections happening there due to the close contact, while mitigation measures mainly target the transmission between households. Therefore, one can see households as boosting the transmission depending on household size. To study the effect of household size and size distribution, we differentiated the within and between household reproduction rate. There are basically no preventive measures, and thus the close contacts can boost the spread. We explicitly incorporated that typically only a fraction of all household members are infected. Thus, viewing the infection of a household of a given size as a splitting process generating a new, small fully infected sub–household and a remaining still susceptible sub–household we derive a compartmental ODE model for the dynamics of the sub–households. In this setting, the basic reproduction number as well as prevalence and the peak of an infection wave in a population with given households size distribution can be computed analytically. We compare numerical simulation results of this novel household–ODE model with results from an agent–based model using data for realistic household size distributions of different countries. We find good agreement of both models showing the catalytic effect of large households on the overall disease dynamics.
2023-01-11T00:00:00ZAllogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic ImpactMrozikiewicz-Rakowska, BeataSzabłowska-Gadomska, IlonaCysewski, DominikRudziński, StefanPłoski, RafałGasperowicz, PiotrKonarzewska, MagdalenaZieliński, JakubMieczkowski, MateuszSieńko, DamianGrzela, TomaszNoszczyk, MariaPaleska, BarbaraCzupryniak, LeszekLewandowska-Szumiel, Malgorzatahttps://depot.ceon.pl/handle/123456789/227632023-07-26T15:21:01Z2023-01-12T00:00:00ZAllogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic Impact
Mrozikiewicz-Rakowska, Beata; Szabłowska-Gadomska, Ilona; Cysewski, Dominik; Rudziński, Stefan; Płoski, Rafał; Gasperowicz, Piotr; Konarzewska, Magdalena; Zieliński, Jakub; Mieczkowski, Mateusz; Sieńko, Damian; Grzela, Tomasz; Noszczyk, Maria; Paleska, Barbara; Czupryniak, Leszek; Lewandowska-Szumiel, Malgorzata
Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human diabetic foot ulcer treatment, in combination with the analyses of the wound. Equal groups of 23 participants each received fibrin gel with ADSCs or fibrin gel alone. The clinical effects were assessed at four time points: days 7, 14, 21 and 49. Material collected during debridement from a subset of each group was analyzed for the presence of ADSC donor DNA and proteomic changes. The reduction in wound size was greater at all subsequent visits, significantly on day 21 and 49, and the time to 50% reduction in the wound size was significantly shorter in patients who received ADSCs. Complete healing was achieved at the end of the study in seven patients treated with ADSCs vs. one treated without ADSCs. One week after ADSC application, 34 proteins significantly differentiated the material from both groups, seven of which, i.e., GAPDH, CAT, ACTN1, KRT1, KRT9, SCL4A1, and TPI, positively correlated with the healing rate. We detected ADSC donor DNA up to 21 days after administration. We confirmed ADSC-related improvement in wound healing that correlated with the molecular background, which provides insights into the role of ADSCs in wound healing—a step toward the development of cell-based therapies.
2023-01-12T00:00:00ZCOVID-19 mRNA BNT162b2 vaccine immunogenicity among children with a history of paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS)Ludwikowska, Kamila M.Popiel, AnetaMatkowska-Kocjan, AgnieszkaBiela, MateuszWójcik, MartaSzenborn, FilipWielgos, KatarzynaPielka-Markiewicz, EwaZaryczański, JanuszKursa, Miron B.Szenborn, Leszekhttps://depot.ceon.pl/handle/123456789/227622023-07-26T15:04:57Z2023-05-05T00:00:00ZCOVID-19 mRNA BNT162b2 vaccine immunogenicity among children with a history of paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS)
Ludwikowska, Kamila M.; Popiel, Aneta; Matkowska-Kocjan, Agnieszka; Biela, Mateusz; Wójcik, Marta; Szenborn, Filip; Wielgos, Katarzyna; Pielka-Markiewicz, Ewa; Zaryczański, Janusz; Kursa, Miron B.; Szenborn, Leszek
We conducted a prospective cohort study of 20 patients with a history of paediatric multisystem inflam- matory syndrome temporally associated with COVID-19 (PIMS group, median age seven years, 70% male) and 34 healthy controls without such a history (CONTROL group, median age eight years, 38% male) aged 5–12 years, to assess the immunogenicity of Pfizer-BioNTech COVID-19 mRNA BNT162b2 vaccine (ComirnatyÒ). Patients received two doses of COVID-19 mRNA BNT162b2 vaccine (10 ug/dose) 21 days apart. Pre-vaccine anti-S SARS-CoV-2 IgG antibodies were measured on the day of the first dose and at the median of 23 days after the second dose. The study was conducted during the COVID-19 wave dominated by the Omicron variant of the virus. Anti-NCP SARS-CoV-2 IgG antibodies were measured twice to evaluate incidents of infection during the study period. Pre-vaccine quantification of both types of antibodies allowed us to differentiate patients into COVID-19 naive and previously infected in order to compare hybrid immunity with vaccine-induced immunity.
Before vaccination, anti-S IgG serum geometric mean concentration (GMC) was 61.17 BAU/ml in the PIMS group and 24.97 in the CONTROL group, while post-vaccination GMC was 3879.14 BAU/ml and 3704.87 BAU/ml, respectively, and did not significantly differ between the groups. Hybrid immunity (regardless of PIMS history) resulted in a higher concentration of SARS-CoV-2 anti-S antibodies after vaccination. Four (20%) of the children in the PIMS group and 11 (32%) in the CONTROL group got infected with SARS-CoV-2 during the study period, yet all of them asymptomatically, and this event has not significantly altered post-vaccination anti-S titers.
In conclusion, COVID-19 vaccination was highly immunogenic in children, including those with a history of PIMS-TS; hybrid immunity overperforms vaccine-induced immunity in terms of serological response in children. However, vaccination effectiveness in preventing SARS-CoV-2 infections in children should be further evaluated.
2023-05-05T00:00:00Z